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The Sirtris Compounds: Worthless?

Friday, January 22nd, 2010

Recent investigation has revealed that the synthetic version of Resveratrol that Sirtris developed and is now the property of Glaxo may be worthless.  While the Sirtris compounds looked like activators initially, it now appears from screens done by Pfizer that the synthetic analog may not be as effective as natural resveratrol.

Pfizer researchers, who screened the Sirtris compound, claim that the reported Sirtris compounds do not do what they are claimed to do, neither in vitro nor in vivo, and are worthless as model compounds for anything in this area of study unlike natural resveratrol which has been shown to definitely activate Sirtuins.

Read more on Corante.

Human: Haiti Needs Long-Term Help, Doctor Says

Thursday, January 21st, 2010

As relief workers struggle to help the Haitian earthquake victims, they face enormous challenges. Dr. Howard McCollister, who’s taught in a hospital on the island for nearly 20 years, talks about what the impoverished nation needs from the world …

View video on Discovery.com

How Cocaine Scrambles Genes in the Brain

Thursday, January 21st, 2010

How Cocaine Scrambles Genes in the Brain a study published in the Jan. 8 issue of Science shows how cocaine alters the way the very genes in your brain.

Read more on Time.com

Optogenetics: controlling brain cells with lasers

Wednesday, January 20th, 2010

Optogenetics: controlling brain cells with lasers Brain cells can be switched on and off like light bulbs using microbial proteins – we explain the process and its implications

Read more on New Scientist.

Cellphone radiation is good for Alzheimer’s mice

Tuesday, January 19th, 2010

Cellphone radiation is good for Alzheimer’s mice After years of demonisation, mobile phones might actually do us more good than harm

Read more on New Scientist.

Obesity Now Poses as Great a Threat to Quality of Life as Smoking

Monday, January 18th, 2010

As the US population becomes increasingly obese while smoking rates continue to decline, obesity has become an equal, if not greater, contributor to the burden of disease and shortening of healthy life.

Read more on Science Daily.

New Key Factor Identified in the Development of Alzheimer’s Disease

Sunday, January 17th, 2010

A small protein found in the gene- ß -amyloid precursor protein, APP, has been identified as a novel factor for the development of Alzheimer’s disease related endosome abnormalities,

Read more on Science Daily.

Vitamin C ‘Cures’ Mice With Accelerated Aging Disease

Saturday, January 16th, 2010

In the research report, a team of Canadian scientists shows that vitamin C stops and even reverses accelerated aging in a mouse model of Werner’s syndrome, but the discovery may also be applicable to other progeroid syndromes.

Read more on Science Daily.

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