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Resveratrol encapsulation may boost bio-availability

Saturday, May 22nd, 2010

Microencapsulation of resveratrol may prolong the release of the compound and improve it’s absorption, claims a new study from China.

Encapsulating the ingredient in a mixture of chitosan and vanillin was found to reduce degradation of resveratrol associated with light and heat. According to findings published in Food Chemistry, the encapsulated resveratrol was slowly released under conditions designed to mimic the stomach and intestine, which could improve the absorption of the compound.

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Resveratrol could help Thalassemia sufferers

Friday, May 21st, 2010

Biotivia Biceuticals has entered into a collaboration with the University of Ferrara to investigate the potential theraputic effects of its proprietary Resveratrol on Beta Thalassemia patients at two hospitals in Italy and one in Egypt. The Thal Lab, under the university’s department of Biochemistry and Molecular Biology, is headed by Dr. Roberto Gambari, physician, professor and acknowledged world expert on Thalassemia, Cystic Fibrosis and Sickle Cell Anemia. He will design, manage and analyze the human clinical trials to begin in the last quarter of 2010.

The human clinical trial, which was prompted by extremely positive data from in-vitro trials at the university, will track the progress of patients receiving 250mg to 5,000mg per day of Bioforte and Transmax Trans-Resveratrol supplements from Biotivia.

James Betz, Managing Director of Biotivia, said: “I am honored by the trust that Dr Gambari and the research team have placed in Biotivia. With a carrier rate of up to 18% in some countries, Thalassemia is a tragedy that the world has hardly heard about. This dreadful condition ruins the life of so many children and adults worldwide. It was a very satisfying day for Biotivia and for Resveratrol research when we were approached to collaborate on this study. The data from this study will add substantially to the growing body of scientific evidence of this remarkable compounds potential health benefits. If the results warrant, patients who now must undergo monthly whole blood transfusions may be freed of this burden”

What is Thalassemia?

Thalassemia (English spelling, “thalassaemia”) is an inherited autosomal recessive blood disease. In Thalassemia, the genetic defect results in reduced rate of synthesis of one of the globin chains that make up hemoglobin. Reduced synthesis of one of the globin chains can cause the formation of abnormal hemoglobin molecules, thus causing anemia, the characteristic presenting symptom of those with Thalassemia.

Generally, Thalassemia sufferers are prevalent in populations that evolved in humid climates where malaria was endemic. It affects all races, as Thalassemia protected these people from malaria due to the blood cells’ easy degradation.

Thalassemia is particularly associated with people of Mediterranean origin, Arabs and Asians. The Maldives has the highest incidence of Thalassemia in the world with a carrier rate of 18% of the population. The estimated prevalence is 16% in people from Cyprus, 1% in Thailand, and 3-8% in populations from Bangladesh, China, India, Malaysia and Pakistan. There are also prevalence’s in descendants of people from Latin America and Mediterranean countries (e.g. Greece, Italy, Portugal, Spain, and others). A very low prevalence has been reported from people in Northern Europe (0.1%) and Africa (0.9%), with those in North Africa having the highest prevalence.

Ancient Egyptians also suffered from Thalassemia, with as many as 40% of studied pre-dynastic and dynastic mummies found to carry the genetic defect. Today, it is particularly common in populations of indigenous ethnic minorities of Upper Egypt such as the Beja, Hadendoa, Saiddi and also peoples of the Nile Delta, Red Sea Hill Region and especially amongst the Siwans.

(Source: Wikipedia. See link below).

How big is the problem?

Thalassemia is the most common inherited single gene disorder in the world. Scientists and public health officials predict that Thalassemia will become a worldwide issue in the next century. With global improvements in childhood disease prevention and treatment, more focus will be given to diagnosing disorders.

The Thalassemia sufferers are a diverse group of genetic blood diseases characterized by absent or decreased production of normal hemoglobin, resulting in a microcytic anemia of varying degree. They are mostly found to be located in areas where malaria is common.

People with Thalassemia Minor are able to fight malaria better than those who do not have it – therefore, in parts of the world where malaria existed Thalassemia Minor increased. This was of great value in the past since malaria was rampant and deadly. However, malaria is no longer a problem in many areas of the world, and Thalassemia Minor has no advantage to people in these areas.

The alpha Thalassemia carriers are concentrated in South-east Asia, Malaysia and southern China.

The beta Thalassemia sufferers are seen primarily in the Mediterranean Sea area, Africa and South-east Asia. Due to global migration patterns, there has been an increase in the incidence of Thalassemia in North America in the last ten years.

(Source: Children’s Cancer and Blood Foundation. See link below).

Research notes.

Readers might find the following research pages of interest:

Medical Research paper by Dr Gambari : Foetal haemoglobin inducers and thalassaemia

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809505/

Gambari article on page 45 of publication : Thalassaemia International Federation.

https://docs.google.com/viewer?url=http://www.thalassaemia.org.cy/pdf/magazine/Issue%252056.pdf&pli=1

Wikipedia – about Thalassemia

http://en.wikipedia.org/wiki/Thalassemia

Children’s Cancer and Blood Foundation : Thalassemia page

http://childrenscbf.org/index.php/medical/single/what_you_need_to_know_about_thalassemia/?gclid=CL3V4uG8uqECFQI9lAodBHOv-Q

Donate : Readers wishing to donate to the Children’s Cancer and Blood Foundation can so here.

https://npo.networkforgood.org/Donate/Donate.aspx?npoSubscriptionId=1002644

More information about Resveratrol supplements at www.biotivia.com

Notes.

This article has not been endorsed by the University of Ferrara or the University of Pisa. Copyright of all research sources used in this article is acknowledged.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Coffee’s anti-diabetes benefit strengthen

Thursday, May 20th, 2010

Regular coffee drinking may reduce levels of inflammatory markers linked to diabetes, according to new findings from a human study.
Scientists from Germany, Finland and Denmark report that daily coffee consumption was associated with improved cholesterol levels and blood levels of inflammatory compounds such as interleukin-18 …

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Cloves are the Best Antioxidant, Says New Study

Tuesday, May 18th, 2010

New research from the Miguel Hernandez University (UMH) has found that cloves (Syzygium aromaticum) are the “best” natural antioxidant. The study examined five antioxidant properties, with cloves showing amazing results for each.
Cloves are used primarily in cooking throughout the world but found primarily in Indian cuisine …

Lifting Heavier Weights to Slim Down

Sunday, May 16th, 2010

Most people think the best way to tone up and slim down is to lift lighter weights more often. But in today’s “Really?” column, Anahad O’Connor debunks that notion, suggesting you’ll get better results with heavier weights…

Read more on the New York Times

Resveratrol Pills, The Best Anti Oxidant

Wednesday, May 12th, 2010

In a recent broadcast of The Oprah Winfrey Show, Dr. Oz who discussed and recommended the anti-aging supplement called Resveratrol. The main property of the supplement is from the skins of red grapes and has been shown to elevate energy levels and increase longevity …

Read more on eBook Route

Spice cabinet perks up food, fortitude

Monday, May 10th, 2010

When you toss oregano into spaghetti sauce, you’re adding in a dose of antioxidant power with the peppery Italian flavor.

Sprinkling cinnamon into yogurt not only will provide that musky sweet kick, but it may help regulate blood sugar and relieve nausea…

Read more on LSJ

Antioxidants show benefits for over-50 sporty-types

Thursday, May 6th, 2010

Supplements containing antioxidants and arginine may boost athletic performance for the over-50s, says a new study from the US. The combination supplement was associated with a 17 per cent increase in the anaerobic threshold – the amount of work done before lactic acid begins to accumulate in the blood, according to findings published in the Journal of the International Society of Sports Nutrition …

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