Biotivia Blog
- Recent Articles
- Free Radical Theory Of Aging: Is Your Body Under Attack?
- The Biology of Aging: Implications for Diseases of Aging and Healthcare in the 21st Century
- Mike Adams Resveratrol Report
- Study Suggests That Resveratrol May Be Key In Ageing Process
- New Resveratrol Capsules Introduced In Britain
- Resveratrol shown in study to combat aging
- Resveratrol Popularity Grows Internationally
- Resveratrol May Lead to a Decrease in Body Fat
- Acai extracts show brain health and cognitive potential
- Biotivia Launch The World’s First Pterostilbene Supplement
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A recent in-vitro study undertaken by researchers at Aarhaus University, in Denmark, has found that resveratrol may improve the metabolic [...]
How to pick the best Resveratrol supplement The exponential increase in demand for natural products that produce health effects comparable [...]
This is your brain on Bioforte A brand new peer reviewed double blind human clinical trial was published this month [...]
Dr. Doug Watt of the Harvard Medical School has been kind enough to allow Biotivia to post his latest Alzheimer’s [...]
Biotivia Bioceuticals, the leading manufacturer and distributor of Resveratrol based supplements and nutraceutical-enriched skin care treatments, has formulated a weight [...]
Only during the last decade has the process of human aging been understood as a disease that can be treated, [...]
Resveratrol Shown To Reduce Inflammation
Tuesday, November 30th, 2010New York City, N.Y (MMD Newswire) September 27, 2010 — A recent study has again shown that resveratrol, a phytoalexin found in the skin of fruit, berries and the Japanese Knotweed plant, can help to reduce inflammation. The results also showed that the antioxidant levels of resveratrol helped to combat free radicals, the main cause of age related diseases.
The study included 20 adults who were given either a supplement of Resveratrol or a placebo, once a day for six weeks. The results showed that the group taking the resveratrol had lower levels of inflammation in their blood vessels compared to the placebo group. The researchers concluded that resveratrol could help benefit those suffering from many age related diseases including cardiovascular, diabetes and cognitive health …
Probiotics And Counselling Shown To Promote Weight Loss In New Mothers
Sunday, November 28th, 2010New York City, N.Y (MMD Newswire) November 2, 2010 — A recent study in Finland has investigated the effects of probiotics on the waist size of new mothers to see, if combined with counseling, these friendly bacteria can help to reduce fat accumulation…
Danish researchers finally solve the obesity riddle
Friday, November 26th, 2010Researchers at the Faculty of Life Sciences (LIFE), University of Copenhagen, can now unveil the results of the world’s largest diet study: If you want to lose weight, you should maintain a diet that is high in proteins with more lean meat, low-fat dairy products and beans and fewer finely refined starch calories such as white bread and white rice. With this diet, you can also eat until you are full without counting calories and without gaining weight. Finally, the extensive study concludes that the official dietary recommendations are not sufficient for preventing obesity.
Green tea extract may boost heart health for obese
Thursday, November 25th, 2010Daily supplements of an extract of green tea may reduce levels of a protein linked to heart disease, says a new study from the US.
Obese people with metabolic syndrome experienced decreases in levels of amyloid alpha, said to be a risk factor for cardiovascular disease, after drinking green tea or taking green tea extracts, scientists from Oklahoma State University and the University of Oklahoma report in Nutrition …
Read more on Nutra Ingredients
Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation
Sunday, November 21st, 2010Resveratrol, an antioxidant polyphenol from red wine, has been the subject of intense interest in recent years due to a range of unique anti-aging properties.
These include cardiovascular benefits via increased nitric oxide production, down-regulation of vasoactive peptides, lowered levels of oxidized low-density lipoprotein, and cyclooxygenase inhibition; possible benefits on Alzheimer’s disease by breakdown of beta-amyloid and direct effects on neural tissues; phytohormonal actions; anticancer properties via modulation of signal transduction, which translates into anti-initiation, antipromotion, and antiprogression effects; antimicrobial effects; and sirtuin activation, which is believed to be involved in the caloric restriction-longevity effect.
Here we report a resveratrol-based skin care formulation, with 17 times greater antioxidant activity than idebenone. The role of resveratrol in prevention of photoaging is reviewed and compared with other antioxidants used in skin care products.
Resveratrol prevents UV damage to skin
Thursday, November 18th, 2010Multiple exposures to solar ultraviolet (UV) radiation cause critical damages that may lead to the development of several cutaneous disorders including skin cancer, the most frequently diagnosed malignancy in the USA. Therefore, efforts are needed to: (i) study the mechanism(s) of UV-mediated cutaneous damages, and (ii) design novel approaches for the management of skin cancer. ‘Chemoprevention’ via plant-based agents may be a useful approach for the management of neoplasia.
Here, we evaluated the involvement of cell cycle regulatory molecules during resveratrol-mediated protection from multiple exposures of UVB (180 mJ/cm2; on alternate days 
7 exposures) radiations in the SKH-1 hairless mouse skin. Resveratrol was topically applied on the skin of SKH-1 hairless mice at a dose of 10 
mol/mouse (in 0.2 ml acetone; 30 min prior to each UVB exposure). Studies were performed at 24 h following the last UVB exposure.
Topical application of resveratrol resulted in significant decrease in UVB-induced bi-fold skin thickness, hyperplasia, and infiltration of leukocytes. The data from immunoblot and/or immunohistochemical analyses revealed that multiple exposure to UVB radiations causes significant upregulation in: (i) proliferating cell nuclear antigen (PCNA), a marker of cellular proliferation, and (ii) cyclin-dependent kinase (cdk)-2, -4 and -6, cyclin-D1, and cyclin-D2.
Resveratrol treatment resulted in significant downregulation in UV-mediated increases in these critical cell cycle regulatory proteins. An interesting observation of this study was that resveratrol treatment resulted in a further stimulation of UVB-mediated increases in cyclin kinase inhibitor WAF1/p21 and tumor suppressor p53.
Further, resveratrol was also found to cause significant decreases in UVB-mediated upregulation of: (i) the mitogen-activated protein kinase kinase, and (ii) the 42 kDa isotype of mitogen-activated protein kinase (MAPK). Thus, our data suggested that the antiproliferative effects of resveratrol might be mediated via modulation in the expression and function of cell cycle regulatory proteins cyclin-D1 and -D2, cdk-2, -4 and -6, and WAF1/p21.
Our data further suggest that the modulation of cki–cyclin–cdk network by resveratrol may be associated with inhibition of the MAPK pathway. We suggest that resveratrol may be useful for the prevention of UVB-mediated cutaneous damages including skin cancer.
Resveratrol study highlights weight loss potential
Monday, November 15th, 2010Anti-inflammatory properties of resveratrol can help in the battle with the bulge.
A recent in-vitro study undertaken by researchers at Aarhaus University, in Denmark, has found that resveratrol may improve the metabolic profile of people with obesity.
The results, published in the International Journal of Obesity, found that resveratrol had an anti-inflammatory effect that reduced the production of compounds, called adipokines, from secreting into human fat cells.
Resveratrol Suppressed Herpes Virus when applied to skin
Friday, November 12th, 2010Resveratrol (3,5,4′-trihydroxystilbene) is a natural component of certain foods, such as grapes, that has been shown to have anti-herpes simplex virus (HSV) activity in vitro. To determine if it is active in vivo, the abraded epidermis of SKH1 mice were infected with HSV-1 and topically treated with 12.5 or 25% resveratrol cream or cream only.
Initial studies demonstrated that: (1) 25% resveratrol cream topically applied two, three, or five times a day effectively suppressed lesion development whereas 12.5% resveratrol cream effectively suppressed lesion formation when applied five times a day starting 1 h after infection; (2) when treatment was begun 1, 6, or 12 h after infection, both 12.5 and 25% resveratrol were effective at 1 and 6 h after infection, but not if applied 12 h after infection.
Comparative studies between resveratrol cream, 10% docosanol cream (Abreva™) and 5% acyclovir ointment (Zovirax™) were also carried out. When treatment was begun 1 h after infection and repeated every 3 h five times a day for 5 days, 12.5 and 25% resveratrol significantly (P=0.0001) inhibited the development of HSV-1 induced skin lesions. Acyclovir was as effective (P=0.0001) as resveratrol. Animals that were topically treated with docosanol were not protected and developed lesions in a manner indistinguishable from cream only controls.
These studies were repeated with an HSV-1 acyclovir-resistant virus. As before, 12.5 and 25% resveratrol cream effectively suppressed lesion formation. The skin of resveratrol-treated animals showed no apparent dermal toxicity such as erythema, scaling, crusting, lichenification, or excoriation. These studies demonstrate that topically applied resveratrol inhibits HSV lesion formation in the skin of mice.
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