Huntington’s disease (HD) is an inherited, progressive and ultimately fatal neurodegenerative disorder that is characterized by psychiatric, cognitive and motor symptoms. Among the pathways implicated in HD are those involving mitogen-activated protein kinase signaling and particularly the Ras-extracellular signal-regulated kinase (ERK) cascade
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ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington’s disease.
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